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Basil

 

Scikit-ribo

 

A New open-source software has been developed by researchers from Cold Spring Harbor Laboratory and John Hopkins University, to address the need for more accurate measurement of protein translation.  Named Scikit-ribo, the tool enables accurate aminoacyl site prediction and estimates of translational efficiency from either Ribo-seq or RNASeq data.

The software can be downloaded from the Scikit-bibo Github page, https://github.com/hanfang/scikit-ribo. Additionally, Scikit-ribo was published in the bioRxiv preprint server at the following link: http://www.biorxiv.org/content/early/2017/06/27/156588

YDSOA

Polymerase Chain Reaction is an extremely popular molecular biology technique. However, errors can be present throughout the PCR process, and it can be troublesome to find methods on how to detect and determine these errors. Recently, researchers at Pirogov Russian National Research Medical University in Moscow, Russia have demonstrated a method to use high-throughout assays that can determine errors within PCR. These researchers recently had their findings published in Nature Scientific Reports, in a paper titled A High-Throughput Assay for Quantitative Measurement of PCR Errors.

In the paper, Shagin et al describe their five-step protocol for the high-throughout sequencing assay for quantification of errors in PCR. A schematic image of this protocol can be seen below: 

 

High-throughput Assay to Determine PCR Errors

The full protocol, alongside the researcher's articles, can be seen at the following link: https://www.nature.com/articles/s41598-017-02727-8

 

YDSOA

In the latest online publication of BMC Genomics, researchers at The University of Toledo demonstrate their Bioinformatic approach at deciphering human relatedness and ancestry. Led by Dr. Alexei Fedorov and his Doctoral student, Rajib Dutta, their research article, titled Intricacies in Arrangement of SNP Haplotypes Suggest “Great Admixture” That Created Modern Humans, demonstrated their approach. Using the haplotypes built from common SNPS, and computer simulation, they postulate that a "Great Admixture" event occurred that created modern-day humans. They believe that this mixture occurred somewhere between 100 and 300 thousands years ago between two ancestral populations. 

Be sure to read their full article: 

https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3776-5

 

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